This study investigated the relationship between plasma aldosterone concentration (PAC) and left ventricular hypertrophy (LVH) and diastolic dysfunction in hypertensive individuals of African and Caucasian backgrounds. Black subjects had higher blood pressure, lower dyslipidemia prevalence, lower renin and PAC levels, and higher left ventricular mass index (LVMI) and E/E’ ratio compared to white subjects. PAC was positively correlated with LVMI and E/E’ in black subjects but not in white subjects, even after adjusting for other factors. The study concludes that aldosterone plays a role in cardiac remodeling and diastolic function specifically in hypertensive individuals of African origin, necessitating further research to understand ethnic differences.
